Compazine (Prochlorperazine) – What You Need to Know

If you’ve been prescribed Compazine, you probably wonder what it does and how to use it safely. In plain language, Compazine is the brand name for prochlorperazine, a medication that belongs to the phenothiazine class. It’s most often used to stop nausea, control vomiting, and treat severe dizziness (vertigo). Some doctors also prescribe it for certain psychiatric conditions like schizophrenia, but the anti‑nausea role is the most common.

How to Take Compazine Correctly

Compazine comes in tablets, suppositories, and injectable forms. The exact dose depends on why you’re taking it, your age, and any other health issues you have. For adults with nausea, the usual oral dose starts at 5 mg three to four times a day. Your doctor may increase it to 10 mg three times daily if needed, but they rarely go higher than 20 mg per day. If you’re using the suppository, the typical adult dose is 10 mg once a day.

Always swallow tablets whole; don’t crush or chew them unless your doctor says it’s okay. Take the medication with a full glass of water, and try to keep a consistent schedule so blood levels stay stable. If you miss a dose, take it as soon as you remember—unless it’s almost time for the next one, then just skip the missed dose. Never double up.

Common Side Effects and When to Seek Help

Most people tolerate Compazine well, but you might notice some predictable reactions. The most common ones include:

• Drowsiness or feeling light‑headed
• Dry mouth
• Constipation
• Blurred vision
• Feeling restless or restless‑leg‑type sensations (known as akathisia)

These usually fade after a few days as your body adjusts. If you experience any of the following, call your doctor right away:

• Severe muscle stiffness or tremors
• High fever, sweating, fast heartbeat, or sudden confusion (signs of a rare but serious reaction called neuroleptic malignant syndrome)
• Uncontrolled shaking or uncontrollable movements
• Signs of an allergic reaction – rash, itching, swelling, or trouble breathing

Because Compazine can affect the brain’s dopamine pathways, it’s also linked to a small risk of tardive dyskinesia, especially with long‑term use. Discuss any unusual facial movements with your healthcare provider promptly.

Drug Interactions You Should Watch

Compazine can interact with several other medicines. Antihistamines, other antipsychotics, and certain antidepressants (like SSRIs) may increase sedation or cause heart rhythm changes. Alcohol amplifies drowsiness, so it’s best to avoid drinking while on this drug.

If you’re on heart‑rate‑controlling meds (beta‑blockers) or drugs that affect the QT interval (like certain antibiotics or anti‑arrhythmics), tell your doctor because Compazine can lengthen that interval too. Always hand your pharmacist a complete list of what you’re taking, including over‑the‑counter products and supplements.

Quick FAQ

Can I drive while on Compazine? Not until you know how it affects you. Start with a low dose, see if you feel drowsy, and avoid driving or operating heavy machinery until you’re sure you’re alert.

Is it safe during pregnancy? Compazine is labeled as Pregnancy Category C. That means risk can’t be ruled out, so only use it if the benefit outweighs the potential danger. Talk to your OB‑GYN.

What should I do if I take more than prescribed? Contact emergency services or a poison control center right away. An overdose can cause severe drowsiness, low blood pressure, or irregular heartbeat.

Can I stop Compazine suddenly? For short‑term nausea treatment, you can stop after the symptoms clear. For long‑term psychiatric use, tapering under doctor supervision is recommended to avoid withdrawal effects.

Bottom line: Compazine is a handy tool for battling nausea and vertigo, but like any medication, it works best when you follow the dosing instructions, watch for side effects, and keep an open line with your healthcare team. If you have any doubts, ask your pharmacist or doctor—better safe than sorry.